The group of Prof. Dr. Andreas Kirschning is focused on natural product chemistry employing means and techniques of both chemistry and biology, while another main field of research represents the development of enabling methods in organic synthesis with emphasis on microreactor technology.
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Preparation of new alkyne-modified ansamitocins by mutasynthesisBeilstein J. Org. Chem. 2014, 10, 535-543.
The preparation of alkyne-modified ansamitocins by mutasynthetic supplemen-tation of Actinosynnema pretiosum mutants with alkyne-substituted amino-benzoic acids is described. This modification paved the way to introduce a thiol linker by Huisgen-type cyclo addition which can principally be utilized to create tumor targeting conjugates. In bioactivity tests, only those new ansami- tocin derivatives showed strong antiproliferative activity that bear an ester side chain at C-3.
Total Synthesis of the Antibiotic Elansolid B1Org. Lett. 2014, 16, 568-571.
The antibiotic elansolid B1 was prepared by a convergent strategy that relied on a highly diastereoselective, biomi- metic intramolecular Diels − Alder cycloaddition (IMDA) that furnished the tetrahydroindane unit. Other key features are a double Sonogashira cross-coupling and a substrate- controlled Yamamoto aldol reaction.
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Ph.D. studentships available
There are currently Ph.D. studentships available in the area of microbiological chemistry in the research group of Professor Russell Cox.