The Kirschning Group

A. Kirschning

Prof. Dr. Andreas Kirschning




Andreas Kirschning was born in Hamburg and studied chemistry at the University of Hamburg and at Southampton University (UK). In Hamburg he joined the group of Prof. E. Schaumann and received his Ph. D. there in 1989. After a postdoctoral stay at the University of Washington (Seattle) with Prof. H. G. Floss, he started his independent research at the Technical University of Clausthal in 1991. Since then he has held positions as guest professor at several universities across Europe and in the U.S.A.. He received during his career a DAAD, a Fritz Prosiegel and Feodor Lynen scholarship. Since 2000 he holds a chair at the University of Hannover.



Chemistry studies at the University of Hamburg


Chemistry studies at Southampton University, UK;      final examination for B. Sc.


Diploma thesis (Prof. Dr. E. Schaumann, University of Hamburg)


Ph.D. thesis (Prof. Dr. E. Schaumann, University of Hamburg) on synthetic organo-silica chemistry


Post-doctoral fellowship with Prof. H. G. Floss (University of Washington, Seattle, USA): Biosynthetic studies on macrolactam antibiotics

04/91- 06/96

Habilitation (Technical University of Clausthal): Synthetic and biosynthetic studies on deoxyglycoconjugates

since 10/2000

Professor at the Institute of Organic Chemistry, Leibniz University of Hannover

Main research topics

Enabling technologies in organic synthesis:

Microstructured flow reactors, inductive heating, multistep flow synthesis of drugs

Natural product chemistry:

Total, semi- and mutasynthesis of biologically active natural products: antiinfectives, antitumor agents,antiviral agents; natural products as tools for drug; finding and evaluation of  biological targets.

Chemistry as tool in RegenerativeTherapies:

Biocompatible (bio)materials for medical implants: synthesis of materials, surface functionalisation, drugable molecules for stem cell research

Fellowships / Awards

DAAD-study scholarship for UK (1983-84)
Fritz-Prosiegel-scholarship (1989)
Feodor-Lynen-scholarship of the Alexander-von-Humboldt-Foundation (1989-90)

Novartis Lectureship Award (2013)

Guest professorships

Humboldt-Universität zu Berlin (1997)
University of Wisconsin, U.S.A. (1998)
Université de Rennes, France (2003)
Université Le Mans, France (April/May 2007)
Università di Roma “La Sapienza”, Italy (October 2007)
Université de Strasbourg Ecole européenne de Chimie, Polymères et Matériaux (ECPM) (January-February 2009 to 2011)


Editor of ROEMPP-online (Thieme Publisher)
Editorial Board J. Flow Chem. (since 2010)
Editorial Board of Natural Product Reports (NPR) (since 2007)
Editorial Board of Beilstein Journal of Organic Chemistry (BJOC) (since 2006)
Director of the Institute of Organic Chemistry, University Hannover (since 02/2001)
Member of the Natural Product Forum of the DECHEMA (since 02/2003)
Board member of the DECHEMA section “Chemical Biology” (2005-2009)
Selection commitee of the Studienstiftung des Deutschen Volkes (since 11/1998)


Gesellschaft Deutscher Chemiker (GDCh) (since 1989)
Royal Society of Chemistry (since 2003)
TECHNION Ges. (since 2005)


Click on the links below for access to the corresponding download section.

lectures and handouts

practical work

group seminar – open access

group seminar – internal

Current group


order by time of stay

Dr. Gerald Dräger


Research project: -REBIRTH-

Design of new biomedical polymers and small molecule modulators for stem cell development



M. Sc. Maik Siebke


Research project: Natural Product Synthesis

Studies towards the total synthesis of Myxovalargin



M. Sc. Mona Oltmanns


Research project: Flow Chemistry

Inductive flow synthesis in supercritical water


M. Sc. Clara Oberhauser


Research project: Mutasynthesis

Studies on enzymatic biotransformations 



M. Sc. Therese Planke


Research project: Natural Product Synthesis

 Synthesestudien zu den Cystobactamiden



M. Sc. Peijun Li


Research project: Natural Product Synthesis

 Studies towards the total synthesis of xenovulenes



M. Sc. Alexandra Seemann


Research project: Flow Chemistry

Studies towards the synthesis of terpenes and related compounds in Flow Chemistry



M. Sc. Sibel Tuerkkan


Research project: -REBIRTH-

Preparation of targeted superparamagnetic nanoparticles



M. Sc. Samhita Banerjee


Research project: -REBIRTH-

Studies on polymer design for biomedical application



M. Sc. Janina Meyer


Research project: Total Synthesis

Synthesis of new Carolacton derivatives


M. Sc. Christian Bartens


Research project: Total Synthesis

Synthesis of progeldanamycin derivatives


Dr. Matthew D. Norris


Research project: Flow Chemistry

-Humbolt Bayer Postdoctoral Fellow-

Iterative synthesis in continuous flow


M. Sc. Friederike Schaekel


Research project: Mutasynthesis

Mutasynthesis of  new ansamitocin derivatives


M. Sc. Vanessa Harms


Research project: Mutasynthesis

Studies on biotransformation of terpenes


Dipl.Chem. Tanja Lau


Research project: Total synthesis

Synthesis of chemical probes for studying polyketides biosynthesis


M.Sc. Helge Berneaud


Research project: Natural Product Synthesis

Studies towards the total synthesis of Cebulactam A1 and A2


M.Sc. Cong Duc Tran


Research project: Mutasynthesis

Chemo-biosynthesis of novel terpenoids


B.Sc. Malte Moeller


Research project: Natural Product Synthesis

Total synthesis of new Cystobactamid derivatives


B.Sc. Tim Seedorf


Research project: Natural Product Synthesis

Synthesis of new Carolacton derivatives


B.Sc. Teresa Kösel


Research project: Methodology

Radical substitutions on terpenes by homolytic activation of haloate(I)-complexes


B.Sc. Dominik Werz


Research project: -REBIRTH-

Synthesis of the Rho-kinase inhibitor Y-27632 and derivatives


B.Sc. Göran Schulz


Research project: Methodology

Radical deformylating Metalation of Aldehydes



Click on the links below to learn more about  former group members.






in chronological order


242) A. Kirschning, N. Dibbert, G. Dräger:


Chemical functionalization of polysaccharides – towards biocompatible hydrogels for biomedical applications.

Chem. Eur. J. 2018, 24, 1231 –1240..



241) H. Sommer, M. Braun, B. Schröder, A. Kirschning:


4-Ethoxy-1,1,1-trifluoro-3-buten-2-one (ETFBO), a versatile precursor for trifluoromethyl substituted hetarenes – a short synthesis of Celebrex® (Celecoxib).

Synlett 2018, 29, 121-125.




240) A. Kipke,K.-U. Schöning, M. Yusubov, A. Kirschning:


TEMPO-mediated oxidative deformylation of Aldehydes: Applications in the synthesis of Polyketide fragments.

Eur. J. Org. Chem. 2017, 6906-6913.


239) M. S. Yusubov, P. S. Postnikov, R. Y. Yusubova,A. Yoshimura, G. Jürjens, A. Kirschning, V. V. Zhdankine:


2-Iodoxybenzoic Acid Tosylates: the Alternative to Dess–Martin Periodinane
Oxidizing Reagents

 Adv. Synth. Catal. 2017, 359, 3207-3216


238)  S. Hüttel, G. Testolin, J. Herrmann,T. Planke, F. Gille, M. Moreno, M. Stadler, M. Brönstrup, A. Kirschning, R. Müller:


Discovery and total synthesis of natural cystobactamid derivatives with
superior activity against Gram-negative pathogens

 Angew. Chem. Int. Ed. 2017, 56, 12760-12764


237)  L.-L. Wang, D. Candito, G. Dräger, A. Kirschning:


Synthetic Studies Probing Elansolid Biosynthesis: A para-Quinone Methide Triggered Intramolecular Diels-Alder Reaction

 Eur. J. Org. Chem. 2017, 37, 5582-5591.



236) K. Seidel, A. Balakrishnan, C. Alexiou , C. Janko, R-M Komoll, L.-L. Wang, A. Kirschning, M Ott:


Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates- Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation of Tumour Growth In Vivo

Chem. Eur. J. 2017, 23, 12326-12337.



235) L.-L. Wang, A. Kirschning:


Total synthesis of elansolids B1 and B2

Beilstein J. Org. Chem. 2017, 13, 1280-1287



234) L.-L. Wang, D. Candito, G.  Dräger, J. Herrmann, R. Müller, A. Kirschning:


Harnessing a p-Quinone Methide Intermediate in the Biomimetic Total Synthesis of the Highly Active Antibiotic 20-Deoxy-Elansolid B1

Chem. Eur. J. 2017, 23, 5291-5298.



233) L.-L. Wang, A. Balakrishnan, N.-C. Bigall, D. Candito, J.F. Miethe, Y. Xie, K. Seidel, M. Ott, A. Kirschning:


2A bio-chemosynthetic approach to superparamagnetic iron oxide-ansamytocin conjugates for use in magnetic drug targeting (MDT)

Chem. Eur. J. 2017, 23, 2265-2270.


232) R. Sharma, S. Mohammadi-Ostad-Kalayeh, F. Stahl, C. Zeilinger, G. Dräger, A. Kirschning, P. C. Ravikumar:


Two new labdane diterpenoids and one new β-lactam from the aerial parts of Roylea cinerea 

Phytochem. Lett. 2017, 19, 101-107.


231) S. Ceylan, H. Ch.-H. Law, A. Kirschning, P. H. Toy:


Organocatalytic Alkyne Isomerizations under Flow Conditions Using Heterogeneous Bifunctional Polystyrene Bearing Phosphine and Phenol Groups 

Synthesis 2017, 49, 145-150.



230) N. Dibbert, A. Krause, J.-C. Rios-Camacho, I. Gruh, A. Kirschning, G. Dräger:


A Synthetic Toolbox for the In Situ Formation of Functionalized Homo- and Heteropolysaccharide-Based Hydrogel Libraries 

Chem. Eur. J. 2016, 52, 18777-18786.


229) T. J. Pfeffer, F. Sasse, C. F. Schmidt, S. Lakämper, A. Kirschning, T. Scholz:


The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function

 Eur. J. Med. Chem. 2016, 112, 164-170.


228) J. Donner, M. Reck, S. Bergmann, A. Kirschning, R. Müller, I. Wagner-Döbler:


The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target

Scientific Rep. 2016, 6 , #29677.


227) T. Busch, G. Dräger, E. Kunst, H. Benson, F. Sasse, K. Seims, A. Kirschning:


Synthesis and antiproliferative activity of new tonantzitlolone-derived diterpene derivatives

Org. Biomol. Chem. 2016, 14 , 9040-9045.


226) J. Hoepfner, M. Kleinsorge, O. Papp, M. Ackermann, S. Alfken, U. Rinas, W. Solodenko, A. Kirschning, M. Sgodda, T. Cantz:


Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells

 Cell Bio. Int.  2016, 40 , 534-548.


225) P. M. Perin, S. Haid, R. J. P. Brown, J. Doerrbecker, K. Schulze, C. Zeilinger, M. von Schaewen, B. Heller, K. Vercauteren, E. Luxenburger, Y. M. Baktash, F. W. R. Vondran, S. Speerstra, A. Awadh, F. Mukhtarov, L. M. Schang, A. Kirschning, R. Müller, C. A. Guzman, L. Kaderali, G. Randall, P. Meuleman, A. Ploss,  T. Pietschmann:

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1

 Hepatology 2016, 63, 49-62.


224) F. Gille, A. Kirschning: 


Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation

Beilstein J. Org. Chem. 2016, 12, 564-570.


223)  J. Hartwig, A. Kirschning:   


Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone

Chem. Eur. J. 2016, 22, 3044-3052.


222) T. J. Pfeffer, F. Sasse, C. F. Schmidt, S. Lakämper, A. Kirschning, T. Scholz  


The natural diterpene tonantzitlolone A and its synthetic enantiomer inhibit cell proliferation and kinesin-5 function

Eur. J. Med. Chem. 2016, 112, 164-170.



221 A. Kirschning, F. Gille, M. Wolling:  


Brook Rearrangement as the Key Step in Domino Reactions

 Applications of Domino Transformations in Organic Synthesis Vol. 1 (Science of Synthesis), Georg Thieme Verlag Stuttgart•New-York, 2015, 355-448.

220)  I. Bulyszko, G. Dräger, A. Klenge, A. Kirschning:   


Evaluation of the Synthetic Potential of an AHBA Knockout Mutant of the Rifamycin Producer Amycolatopsis mediterranei

Chem. Eur. J. 2015, 21, 19231-19242.


219)  J. Hartwig, A. Kirschning:   


Iterative Syntheses—The Gateway to New Automation Protocols

Angew. Chem. Int. Ed. 2015, 64, 10412-10414.


218) M. Moreno, W. A. M. Elgaher, J. Herrmann, N. Schläger, M. M. Hamed, S. Baumann, R. Müller, R. W. Hartmann, A. Kirschning:   


Synthesis and Biological Evaluation of Cystobactamid 507: A Bacterial Topoisomerase Inhibitor from Cystobacter sp.

Synlett 2015, 26, 1175-1178.


217) A. Kirschning, T. A. C. Reydon:   

Is organic chemistry science – and does this question make any sense at all?

Beilstein J. Org. Chem. 2015, 11, 893-896.


216)  N. Stumpp, P Premnath, T. Schmidt, J. Ammermann, G. Dräger, M. Reck, R. Jansen, M. Stiesch, I. Wagner-Döbler, A. Kirschning:   


Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria

Org. Biomol. Chem. 2015, 13, 5765-5774.


215)  G. Jürjens, A. Kirschning, D. A. Candito:   


Lessons from the Synthetic Chemist Nature

Nat. Prod. Rep. 2015, 32, 723-737.


214)  J. Franke, M. Bock, R. Dehn, J. Fohrer, S. B. Mhaske, A.Migliorini, A. A. Kanakis, R. Jansen, J. Herrmann, R. Möller, A. Kirschning:   


Total and Semi-Syntheses of Antimicrobial Thuggacin Derivatives

 Chem. Eur. J. 2015, 21, 4272-4284.


213)  J. Hermane, I. Bulyszko, S. Eichner, F. Sasse, W. Collisi, A. Poso, E. Schax, J.-G. Walter, T. Scheper, K. Kock, C. Hermann, P. Aliuos, G. Reuter, C. Zeilinger, A. Kirschning:   


New, Non-quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90

Chem. Bio. Chem. 2015, 16, 302-311.



212)  L. Mancuso, T. Knobloch, J Buchholz, J. Hartwig, L. Möller, K. Seidel, W Collisi, F. Sasse, A. Kirschning:    


Preparation of Thermocleavable Conjugates Based on Ansamitocin and Superparamagnetic Nanostructured Particles by a Chemobiosynthetic Approach.

Chem. Synth. J. 2014, 20, 17541-17551.


211)  S. R. Chaudhuri, J. Hartwig, L. Kupracz, T. Kodanek,  A. Kirschning:    


Oxidations of Allylic and Benzylic Alcohols under Inductively- Heated Flow Conditions with Gold-Doped Superparamagnetic Nanostructured Particles as Catalyst and Oxygen as Oxidant

Adv. Synth. Catal. 2014, 356, 3530-3538.


210)  G. Jürjens, A. Kirschning:    


Pushing Flow Chemistry to New Limits: Development of a Flow Process towards Spirangien A.

Chem. Cat. Chem 2014, 6, 2798-2800.


209)  J. Hartwig, J. B. Metternich, N. Nikbin, A. Kirschning, S. V. Ley:    


Continuous flow chemistry: a discovery tool for new chemical reactivity patterns.

Org. Biomol. Chem. 2014, 12, 3611-3615.


208)  G. Jürjens, A. Kirschning:   


Synthesis of a Cytotoxic Ansamycin Hybrid

Org. Lett. 2014, 16, 3000-3003.


207)  S. Umayaparvathi, M. Arumugam, S. Meenakshi, G. Dräger, A. Kirschning, T. Balasubramanian :  

Purification and Characterization of Antioxidant Peptides from Oyster (Saccostrea cucullata) Hydrolysate and the Anticancer Activity of Hydrolysate on Human Colon Cancer Cell Lines

Int. J. Pept. Res. Ther. 2014, 20, 231-243.


206) E. Schax, J.-G. Walter, H. Märzhäuser, F. Stahl, T. Scheper, D. A. Agard, S.
Eichner, A. Kirschning,  C. Zeilinger: 


Microarray-Based Screening for Human
and Bacterial Hsp90 Inhibitors

J.Biotechnol. 2014, 180, 1-9.


 205) E. Weiss, B. Dutta, A. Kirschning, R. Abu-Reziq:  


BMIm-PF6@SiO2 Microcapsules: Particulated Ionic Liquids as A New Material for the Heterogenization of Catalysts

Adv. Synth. Catal. 2014, 356, 3530-3538.


204) E. Geist, A. Kirschning, T. Schmidt:  


sp 3-sp 3 Coupling reactions in the synthesis of natural products and biologically active molecules

Nat. Prod. Rep. 2014, 31, 441-448.


203) K. Harmrolfs, L. Mancuso, B. Drung, F. Sasse, A. Kirschning:  


Preparation of new alkyne-modified ansamitocins by mutasynthesis

Beilstein J. Org. Chem. 2014, 10, 535-543.


202) A. Weber, R. Dehn, N. Schläger, B. Dieter, A. Kirschning:  



Total Synthesis of the Antibiotic Elansolid B1

Org. Lett. 2014, 16, 568-571. 



Highlighted in Synfacts 2014.



 201) E. Schax, J. Neunaber, F. Stahl, J.-G. Walter, T. Scheper, S. Eichner, A. Kirschning, C. Zeilinger:


Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds

Biodiscovery 2014, 14, 1-6. 



200) Y. Su, J. Palacek, A. Kirschning, G. Dräger:


Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for RGD-Modification and Hydrogel Formation

Macromol. Symp. 2013, 334, 82-91.


199) L. Kupracz, A. Kirschning:


Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

Adv. Synth. Catal. 2013, 355, 3375-3380.


198) S. Cludius-Brandt, L. Kupracz, A. Kirschning:


[3+2]-Cycloadditions of nitrile ylides after photo-activation of vinyl azides under flow conditions

Beilstein J. Org. Chem. 2013, 9, 1745-1750.


197) J. Hartwig, S. Ceylan, L. Kupracz , L. Coutable, A. Kirschning:



Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

Angew. Chem. Int. Ed. 2013, 52, 9813-9817.



Highlighted in Synfacts 2013.


196) J. Franke, S. Eichner, C. Zeilinger , A. Kirschning:


Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy

Nat. Prod. Rep. 2013, 30, 1299-1323.


195) L. Mancuso, G. Jürjens, J. Hermane, K. Harmrolfs, S. Eichner, J. Fohrer, W. Collisi, F. Sasse, A. Kirschning:


Bioreduction of Aryl Azides during Mutasynthesis of New Ansamitocins                       

Org. Lett. 2013, 15, 4442-4445.


194) F. Nador, M. A. Volpe, F. Alonso , A. Feldhoff, A. Kirschning, G. Radivoy:


Copper nanoparticles supported on silica coated maghemite as versatile, magnetically recoverable and reusable catalyst for alkyne coupling and cycloaddition reactions

Appl. Catal. A 2013, 455, 39-45.


193) L. Kupracz , A. Kirschning: 


Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones

 J. Flow Chem. 2013, 3, 11-16.


192) M. S. Yusubov, R. Y. Yusubova, V. N. Nemykin, A. V. Maskaev, M. R. Geraskina, A. Kirschning, V. V. Zhdankin:


Potassium 4-iodylbenzenesulfonate: preparation, structure, and application as a reagent for oxidative iodination of arenes

Eur. J. Org. Chem. 2012, 30, 5935-5942.


191) L. Möller, C. Hess, J.Paleček, Yi Su, A. Haverich, A. Kirschning,G. Dräger:


Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide

Beilstein J. Org. Chem. 2013, 9, 270-277.


190) J. Dahlmann, A. Krause, L. Möller, G. Kensah, M. Möwes, A. Diekmann, U. Martin, A. Kirschning, I. Gruh, G. Dräger:


Myocardial tissue engineering based on novel fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels

Biomaterials 2013, 34, 940-951.


189) W. Solodenko, A. Doppiu, R. Frankfurter, C. Vogt, A. Kirschning:


Silica Immobilized Hoveyda Type Pre-Catalysts: Convenient and Reusable Heterogeneous Catalysts for Batch and Flow Olefin Metathesis

Aust. J. Chem. 2013, 66, 183-191.


Highlighted in Synfacts 2013.



188) E. Borré, M. Rouen, I. Laurent, M. Magrez, F. Caijo, C. Crévisy, W. Solodenko, L. Toupet, R. Frankfurter, C. Vogt,A. Kirschning, M. Mauduit:


A Fast-Initiating Ionically-tagged Ru-Complex : A Robust Supported Catalyst for Batch and Continuous Flow Olefin Metathesis

Chem. Eur. J. 2012, 18, 16369-16382.


187) U. Schön, J. Messinger, W. Solodenko, A. Kirschning:


Synthetic Approaches towards 4-Functionalized Estrone Derivatives

Synthesis 2012, 44, 3822-3828.


186) N. Schläger, A. Kirschning:


Substrate-controlled stereoselectivity in the Yamamoto aldol reaction

Org. Biomol. Chem. 2012, 10, 7721-7729.


185) J. Barbier, K. Gerth, R. Jansen, A. Kirschning:


Total synthesis of noricumazole B establishes D-arabinose as glycan unit

Org. Biomol. Chem. 2012, 10, 8298-8307.


184) H. Steinmetz, W. Zander, M.A.M. Shushni, R. Jansen, K. Gerth, R. Dehn, G. Dräger, A. Kirschning, R. Müller:


Precursor-directed syntheses and biological evaluation of new Elansolid derivatives

ChemBioChem 2012, 13, 1813-1817.


183) J. Barbier, J. Wegner, S. Benson, J. Gentzsch, T. Pietschmann, A. Kirschning:


Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition

Chem. Eur. J. 2012, 18, 9083-9090.


182) A. Krause, A. Kirschning, G. Dräger:


Bioorthogonal Metal-free Click-Ligation of cRGD-Pentapetide to Alginate

Org. Biomol. Chem. 2012, 10, 5547-5553.


181) J. Hartwig, L. Kupracz, A. Kirschning:


New Synthetic Opportunities in Miniaturized Flow Reactors with Inductive Heating

Chem. Lett. 2012, 41, 562-570.


180) T. Knobloch, G. Dräger, W. Collisi, F. Sasse, A. Kirschning:


Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

Beilstein J. Org. Chem. 2012, 8, 861-869.


179) F. Taft, S. Eichner, T. Knobloch, K. Harmrolfs, J. Hermane, A. Kirschning:


Ansamitocin Libraries by Combining Mutasynthesis with Chemical Synthesis; A New Version of Total Synthesis

Synlett 2012, 23, 1416-1426.


178) A. Kirschning, F. Hahn:


Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

Angew. Chem. Int. Ed. 2012, 51, 4012-4022.


177) S. Eichner, T. Knobloch, H. G. Floss, J. Fohrer, K. Harmrolfs, J. Hermane, A. Schulz, F. Sasse, P. Spiteller, F. Taft, A. Kirschning:


The Interplay between Mutasynthesis and Semisynthesis: Generation and Evaluation of an Ansamitocin Library

Angew. Chem. Int. Ed. 2012, 51, 752-757.


176) T. Schmidt, A. Kirschning:


Total Synthesis of Carolacton a Highly Potent Biofilm Inhibitor

Angew. Chem. Int. Ed. 2012, 51, 1063-1066.


Highlighted in Synfacts 2012.


175) S. Eichner, T. Eichner, H.G. Floss, J. Fohrer, E. Hofer, F. Sasse, C. Zeilinger, A. Kirschning:


Broad substrate specificity of the amide synthase in S. hygroscopicus new 20-membered macrolactones derived from geldanamycin

J. Am. Chem. Soc. 2012, 134, 1673-1679.


174) J. Wegner, S.V. Ley, A. Kirschning, A.-L. Hansen, J.M. Garcia, I.R. Baxendale:


A Total Synthesis of Millingtonine A                      

Org. Lett. 2012, 14, 696-699.                   


173) J. Wegner, S. Ceylan, A. Kirschning:


Flow Chemistry A Key Enabling Technology for (Multistep) Organic Synthesis

Adv. Synth. Catal. 2012, 354, 17-57.


172) J. Barbier, R. Jansen, H. Irschik, S. Benson, K. Gerth, B. Böhlendorf, G. Höfle, H. Reichenbach, J. Wegner, C. Zeilinger, A. Kirschning, R. Müller:


Isolation and Total Synthesis of Icumazoles and Noricumazoles Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

Angew. Chem. Int. Ed. 2012, 51, 1256-1260.


171) F. Taft, K. Harmrolfs, I. Nickeleit, A. Heutling, M. Kiene, N. Malek, F. Sasse, A. Kirschning:


Combined Muta- and Semisynthesis: A Powerful Synthetic Hybrid Approach to Access Target Specific Antitumor Agents Based on Ansamitocin P3

Chem. Eur. J. 2012, 18, 880-886.



170) L. Möller, A. Krause, I. Bartsch, A. Kirschning, F. Witte, G. Dräger:


Preparation and In Vivo Imaging of Lucifer Yellow Tagged Hydrogels

 Macromol. Symp. 2011, 309-310, 222-228.


169) L. Kupracz, J. Hartwig, J. Wegner, S. Ceylan, A. Kirschning:


Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions

Beilstein J. Org. Chem. 2011, 7, 1441-1448.


Beilstein TV

Inductive heating inside flow reactors


168) J. Paleček, R. Zweigert, R. Olmer, U. Martin, A. Kirschning, G. Dräger:


A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Org. Biomol. Chem. 2011, 28, 7739-7744.


Highlighted in Synfacts 2011.


167) R. Jansen, K. Gerth, H. Steinmetz, S.Reinecke, W. Kessler, A. Kirschning, R. Müller:


Elansolid A3, a Unique p-Quinone Methide Antibiotic from Chitinophaga sancti

Chem. Eur. J. 2011, 17, 7739-7744.


166) Dr. R. Dehn, Dr. Y. Katsuyama, A. Weber, Dr. K. Gerth, Dr. R. Jansen, H. Steinmetz, Prof. Dr. G. Höfle, Prof. Dr. R. Müller, Prof. Dr. A. Kirschning:


Molecular Basis of Elansolid Biosynthesis: Evidence for an Unprecedented Quinone Methide Initiated Intramolecular DielsAlder Cycloaddition/Macrolactonization

 Angew. Chem. Int. Ed. 2011, 50, 3882-3887.


165) L. Möller, A. Krause, J. Dahlmann, I. Gruh, A. Kirschning, G. Dräger:


Preparation and evaluation of hydrogel-composites from methacrylated hyaluronic acid, alginate, and gelatin for tissue engineering

Int .J. Artif. Organs. 2011, 34, 93-102.


164) J. Paleček, G. Dräger, A. Kirschning:


A Practical Large-Scale Synthesis of Cyclic RGD Pentapeptides Suitable for Further Functionalization through ‘Click’ Chemistry

Synthesis, 2011, 4, 653-661.


163) J. Wegner, S. Ceylan, A. Kirschning:


Ten key issues in modern flow chemistry

Org. Biomol. Chem. 2012, 10, 7721-7729.


Highlighted in Faculty of 1000 (F1000), 2011.


162) H. Steinmetz, Dr. K. Gerth, Dr. R. Jansen, N. Schläger, Dr. R. Dehn, S. Reinecke, Prof. Dr. A. Kirschning, Prof. Dr. R. Müller:


Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti Isolated as Two Stable Atropisomers

Angew. Chem. Int. Ed. 2011, 50, 532-536.




161) T. Knobloch, K. Harmrolfs, F. Taft, B. Thomaszewski, F. Sasse, A. Kirschning:


Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-Oriented Approach to Exploit Biosynthetic Flexibility

ChemBioChem. 2011, 12, 540-547.


160) S. Ceylan, L. Coutable, J. Wegner, A. Kirschning:


Inductive Heating with Magnetic Materials inside Flow Reactors

Chem. Eur. J. 2011, 17, 1884-1893.



159) K. Harmrolfs, M. Brünjes, G. Dräger, H. G. Floss, F. Sasse, F. Taft, A. Kirschning:  

Cyclization of Synthetic seco-Proansamitocins to Ansamitocin Macrolactams by Actinosynnema pretiosum as Biocatalyst

ChemBioChem. 2010, 11, 2517-2520. more

158) M.S. Yusubov, R.Y. Yusubova, T.V. Funk, K.-W. Chi, A. Kirschning, V.V. Zhdankin:

m-Iodosylbenzoic Acid as a Convenient Recyclable Hypervalent Iodine Oxidant for the Synthesis of α-Iodo Ketones by Oxidative Iodination of Ketones

Synthesis 2010, 21, 3681-3685. more

157) Yi Su, C. Kasper, A. Kirschning, G. Dräger, S. Berski:

Synthesis of New Polysialic Acid Derivatives

Macromol. Biosci. 2010, 10, 1028-1033. more

156) J. Knochen, U. Kunz, T. Turek, S. Ceylan, A. Kirschning, I. Kampen, M. Vielkind, A. Kwade, S. Arndt, S. Scholl:

µ-Consortium: Installation of a mobile Plant for Education and Training in Micro Process Engineering

Chemie Ingenieur Technik 2010, 1799-1806. more

155) M. Baumann, I.R. Baxendale, A. Kirschning, S.V. Ley, J. Wegner:

Synthesis of Highly Substituted Nitropyrrolidines, Nitropyrrolizines and Nitropyrroles via Multicomponent-Multistep Sequences within a Flow Reactor

Heterocycles 2010, 82, 77. more

154) J. Wegner, S. Ceylan, C. Friese, A. Kirschning:

Inductively Heated Oxides Inside Microreactors – Facile Oxidations under Flow Conditions

Eur. J. Org. Chem. 2010, 23, 4372-4375. more; Highlighted in Synfacts2010, 11, 1313. more

153) S. Ceylan, T. Klande, C. Vogt, C. Friese, A. Kirschning:

Chemical Synthesis with Inductively Heated Copper Flow Reactors

Synlett 2010, 2009-2013. more

152) M. Vogt, S. Ceylan, A. Kirschning:

Stereocontrolled palladium-catalysed umpolung allylation of aldehydes with allyl acetates

Tetrahedron 2010, 66, 6450-6456. more

151) R. Olmer, A. Haase, S. Merkert, W. Cui, J. Paleček, C. Ran, A. Kirschning, T. Scheper, S. Glage, K. Miller, E. C. Curnow, E. S. Hayes, U. Martin:

Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium

Stem Cell Research 2010, 5, 51-64. more

150) R. Jansen, H. Irschik, V. Huch, D. Schummer, H. Steinmetz, M. Bock, T. Schmidt, A. Kirschning, R. Müller:

Carolacton – A Macrolide Ketocarbonic Acid that Reduces Biofilm Formation by the Caries- and Endocarditis-Associated Bacterium Streptococcus mutans

Eur. J. Org. Chem. 2010, 1284-1289.more


149) S. Ceylan, A. Kirschning:

Organic Synthesis with Mini Flow Reactors Using Immobilised Catalysts

in Recoverable and Recyclable Catalysts, Maurizio Benaglia (ed.), John Wiley & Sons. 2009, 379-410. more

148) K. Mennecke, A. Kirschning:

Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki-Miyaura and Heck-Mizoroki reactions under flow conditions

Beilstein J. Org. Chem. 2009, 5: 21. more

147) S. Eichner, H. G. Floss, F. Sasse, A. Kirschning:

New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

ChemBioChem 2009, 10, 1801-1805. more

146) F. Gallier, H. Hussain, A. Martel, A. Kirschning, G. Dujardin:

Hetero-Diels-Alder Reactions of Cyclic Ketone Derived Enamide. A New and Efficient Concept for the Asymmetric Robinson Annulation

Org. Lett. 2009, 11, 3060-3063. more

145) A. Kirschning (Editor):

Chemistry in flow systems

Beilstein J. Org. Chem. 2009, 5. more

144) H. Wen, K. Yao, Y. Zhang, Z. Zhou, A. Kirschning:

Catalytic transfer hydrogenation of aromatic nitro compounds in presence of polymer-supported nano-amorphous Ni-B catalyst

Catal. Commun. 2009, 10, 1207-1211. more

143) F. Taft, M. Brünjes, T. Knobloch, H. G. Floss, A. Kirschning:

Timing of the Δ10,12Δ11,13 Double Bond Migration During Ansamitocin Biosynthesis in Actinosynnema pretiosum

J. Am. Chem. Soc. 2009, 131, 3812-3813. more

142) A. Kirschning, S. Luiken, A. Migliorini, M. A. Loreto, M. Vogt:

Studies on the 1,2-Brook Rearrangement of Bissilyl Ketones

Synlett 2009, 3, 429-432. more


141) M. Bock, R. Dehn, A. Kirschning:

Total Synthesis of Thuggacin B

Angew. Chem. Int. Ed. 2008, 47, 9134-9137. more ; Highlighted in Synfacts 2009, 5, 475. more

140) S. Ceylan, C. Friese, C. Lammel, K. Mazac, A. Kirschning:

Inductive Heating for Organic Synthesis by Using Functionalized Magnetic Nanoparticles Inside Microreactors

Angew. Chem. Int. Ed.2008, 47, 8950-8953. more; Highlighted in Synfacts 2009, 2, 219. more

139) A. Kirschning, L. Gulajski, K. Mennecke, A. Meyer, T. Busch, K. Grela:

Highly Active Ammonium-Tagged Olefin-Metathesis Catalyst for Simplified Purification

Synlett 2008, 17, 2692-2696. more

138) K. Mennecke, A. Kirschning:

Immobilization of NHC-Bearing Palladium Catalysts on Polyvinylpyridine; Applications in Suzuki-Miyaura and Hartwig-Buchwald Reactions under Batch and Continuous-Flow Conditions

Synthesis 2008, 3267-3272.more

137) A. Kirschning, K. Harmrolfs and T. Knobloch:

The chemistry and biology of the maytansinoid antitumor agents

C. R. Chim. 2008, 11, 1523-1543. more

136) T. Busch, H. Schuster, A. Kirschning:

Determination of the absolute configuration of the diterpene tonantzitlolone B

Tetrahedron Lett. 2008, 49, 5273-5275. more

135) S. Berski, J. van Bergeijk, D. Schwarzer, Y. Stark, C. Kasper, T. Scheper, C. Grothe, R. Gerardy-Schahn, A. Kirschning, G. Dräger:

Synthesis and Biological Evaluation of a Polysialic Acid-Based Hydrogel as Enzymatically Degradable Scaffold Material for Tissue Engineering

Biomacromolecules 2008, 9, 2353-2359. more

134) H.-L. Wen, K.-Sh. Yao, J. Wei, Z.-M. Zhou, A. Kirschning:

Preparation and characterization of polymer-supported nano-amorphous Ni-B particles

J. Nanoparticle Res. 2008, 499-503. more

133) K. Mennecke, W. Solodenko, A. Kirschning:

Carbon-Carbon Cross-Coupling Reactions under Continuous Flow Conditions Using Poly(vinylpyridine) Doped with Palladium

Synthesis 2008, 1589-1599. more

132) B. Oelze, D. Albert, A. Kirschning:

Synthetic and structural studies on macrocyclic amino cyclitols – conformational chameleons

Org. Biomol. Chem. 2008, 6, 2412-2425. more

131) U. Schön, J. Messinger, S. Eichner, A. Kirschning:

Comparison of monomode and multimode microwave equipment in Suzuki-Miyaura reactions – en route to high throughput parallel synthesis under microwave conditions

Tetrahedron Lett. 2008, 49, 3204-3207. more

130) A. Kirschning, K. Harmrolfs, K. Mennecke, J. Messinger, U. Schön, K. Grela:

Homo- and Heterogeneous Ru-based Metathesis Catalysts in Cross-Metathesis of 15-Propenyl Estrone – Towards 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Tetrahedron Lett.2008, 49, 3019-3022. more

129) F. Taft, M. Brünjes, H. G. Floss, N. Czempinski, S. Grond, F. Sasse, A. Kirschning:

Highly Active Ansamitocin Derivatives: Mutasynthesis Using an AHBA-Blocked Mutant

ChemBioChem2008, 9, 1057-1060. more

128) K. Mennecke, R. Cecilia, T. N. Glasnov, S. Gruhl, C. Vogt, A. Feldhoff, M. A. Larrubia Vargas, C. O. Kappe, U. Kunz, A. Kirschning:

Palladium(0) Nanoparticles on Glass-Polymer Composite Materials as Recyclable Catalysts: A Comparison Study on their Use in Batch and Continuous Flow Processes

Adv. Synth. Catal.2008, 350, 717-730. more

127) T. Busch, A. Kirschning:

Recent advances in the total synthesis of pharmaceutically relevant diterpenes

Nat. Prod. Rep.2008, 25, 318-341. more

126) S. Hartlieb, A. Günzel, R. Gerardy-Schahn, A. K. Münster-Kühnel, A. Kirschning, G. Dräger:

Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid

Carbohydr. Res.2008, 343, 2075-2082. more

125) M. S. Yusubov, R. Y. Yusubova, A. Kirschning, J. Y. Park, K.-W. Chi:

m-Iodosylbenzoic acid, a tagged hypervalent iodine reagent for the iodo-functionalization of alkenes and alkynes

Tetrahedron Lett.2008, 49, 1506-1509. more

124) E. Kunst, F. Gallier, G. Dujardin, A. Kirschning:

Glycosidations of 2-deoxy glycosyl dithiophosphates using a tagged iodine(III)-promoter for simple purification

Org. Biomol. Chem.2008, 6, 893-898. more

123) M. Bock, K. Buntin, R. Müller, A. Kirschning:

Stereochemical Determination of Thuggacins A-C, Highly Active Antibiotics from the Myxobacterium Sorangium cellulosum

Angew. Chem. Int. Ed.2008, 47, 2308-2311. more

122) S. Luiken, A. Kirschning:

Polymer-Assisted Dithiane Hydrolysis with Minimum Workup

J. Org Chem.2008, 73, 2018-2020. more; Highlighted in Synfacts2008, 6, 660. more

121) M. S. Yusubov, T. V. Funk, K. W. Chi, E. H. Cha, G. H. Kim, A. Kirschning, V. V. Zhdankin:

Preparation and X-ray structures of 3-[Bis(trifluoroacetoxy)iodo]benzoic acid and 3-[hydroxy(tosyloxy)iodo]benzoic acid: new recyclable hypervalent iodine reagents

J. Org. Chem.2008, 73, 295-297. more


120) B. Hickstein, R. Cecilia, U. Kunz, U. A. Peuker, A. Kirschning:

Magnetiseable function particles for the solid phase support synthesis as example of a transfer hydrogenation response

Chem. Ing. Tech. 2007, 79, 2089-2097.

119) E. Kunst, F. Gallier, G. Dujardin, M. S. Yusubov, A. Kirschning:

Tagged Hypervalent Iodine Reagents: A New Purification Concept Based on Ion Exchange through SN2 Substitution

Org. Lett. 2007, 9, 5199-5202.

118) G. Dräger, C. Kiss, U. Kunz, A. Kirschning:

Enzyme-purification and catalytic transformations in a microstructured PASSflow reactor using a new tyrosine-based Ni-NTA linker system attached to a polyvinylpyrrolidinone-based matrix

Org. Biomol. Chem. 2007, 5, 3657-3664.

117) G. Dräger, F. Jeske, E. Kunst, E. G. Lopez, H. V. Sanchez, F. Tsichritzis, A. Kirschning*, J. Jakupovic:

Tonantzitlolone and other Diterpenes from Stillingia sanguinolenta

Eur. J. Org. Chem. 2007, 5020-5026.

116) A. Kirschning*, F. Taft and T. Knobloch:

Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering

Org. Biomol. Chem. 2007, 5, 3245-3259.

115) S. Bruns, Y. Stark, S. Röker, M. Wieland, G. Dräger, A. Kirschning, F. Stahl, C. Kasper, T. Scheper:

Collagen biomaterial doped with colominic acid for cell culture applications with regard to peripheral nerve repair

J. Biotechnol. 2007, 131, 335-345.

114) A. Kirschning, M. S. Yusubov, R. Y. Yusubova, K.-W. Chi, J. Y. Park:

m-Iodosylbenzoic acid – a convenient recyclable reagent for highly efficient aromatic iodinations

Beilstein J. Org. Chem. 2007, 3: 19.

113) T. Jöge, M. Jesberger, P. Bröker, A. Kirschning:

Synthetic access to spacer-linked 3,6-diamino-2,3,6-trideoxy-α-D-glucopyranosides – potential aminoglycoside mimics for the inhibition of the HIV-1 TAR-RNA/Tat-peptide complex

Carbohydr. Res. 2007, 342, 1704-1714.

112) A. Meyer, A. Kirschning:

Total Syntheses of New Proansamitocin Derivates by Ring-Closing Metathesis

Synlett 2007, 8,1264-1268.

111) A. Meyer, M. Brünjes, F. Taft, T. Frenzel, F. Sasse, A. Kirschning:

Chemoenzymatic Approaches toward Dechloroansamitocin P-3

Org. Lett. 2007, 9, 1489-1492.

110) H. Clavier, K. Grela, A. Kirschning, M. Mauduit, S. P. Nolan:

Clean, green and sustainable – new concepts for metathesis

Angew. Chem. Int. Ed.2007, 46, 6786-6801

109) M. S. Yusubov, M. P. Gilmkhanova, V. V. Zhdankin, A. Kirschning*:

m-Iodosylbenzoic Acid as a Convenient Recyclable Reagent for Highly Efficient RuCl3-Catalyzed Oxidation of Alcohols to Carbonyl Compounds

Synlett 2007, 563-566.

108) W. Solodenko, G. Jas, U. Kunz, A. Kirschning*:

Continuous Enantioselective Kinetic Resolution of Terminal Epoxides Using Immobilized Chiral Cobalt-Salen Complexes

Synthesis 2007, 583-589.

107) E. Schaumann*, A. Kirschning:

Domino synthesis of carbo- and heterocycles involving 1,3 or 1,4 C-O silyl migration

Synlett 2007, 177-190.

106) M. Vaultier, A. Kirschning, V. Singh:

Task-specific Ionic Liquids as New Phases for Supported Organic Synthesis, Ionic Liquids in Synthesis (eds.: P. Wasserscheidt, T. Welton)

Wiley-VCH 2007, Vol. 2, 488-527, ISBN-13: 978-3-527-31239-9.

105) A. Kirschning, C. Kujat, S. Luiken, E. Schaumann:

Small and versatile – Formyl anion and formyl dianion equivalents

Eur. J. Org. Chem 2007, 2387-2400.

104) D. Kashin, A. Meyer, R. Wittenberg, K.-U. Schöning, S. Kamlage, A. Kirschning*:

A practical Synthesis of the Ansa Chain of Benzenic Ansamycin Antibiotics: Total Synthesis of Ansatrienol Derivative

Synthesis 2007, 2, 304-319.

103) K. M. Dawood, W. Solodenko, A. Kirschning*:

Microwave-accelerated Mizoroki-Heck- and Sonogashira Cross Coupling Reactions in Water Using a Heterogeneous Palladium(II)-Precatalyst

ARKIVOC 2007, 104-124.


102) A. Michrowska, K. Mennecke, U. Kunz, A. Kirschning, K. Grela:

A New Concept for the Noncovalent Binding of a Ruthenium-Based Olefin Metathesis Catalyst to Polymeric Phases: Preparation of a Catalyst on Raschig Rings

J. Am. Chem. Soc. 2006, 128, 13261-13267.

101) C. Jasper, A. Adibekian, T. Busch, M. Quitschalle, R. Wittenberg, A. Kirschning:

Total Synthesis of Cyclic Diterpene Tonantzitlolone Based on a Highly Stereoselective Substrate-Controlled Aldol Reaction and Ring-Closing Metathesis

Chem. Eur. J. 2006, 12, 8719-8734.

100) A. Michrowska, L. Gulajski, Z. Kaczmarska, K. Mennecke, A. Kirschning, K. Grela:

A green catalyst for green chemistry – Synthesis and application of an olefin metathesis catalyst bearing a quaternary ammonium group

Green Chem. 2006, 8, 685-688.

99) D. Raghunathan, V. M. Sánchez-Pedregal, J. Junker, C. Schwiegk, M. Kalesse, A. Kirschning, T. Carlomagno:

TAR-RNA recognition by a novel cyclic aminoglycoside analogue

Nucleic Acids Res. 2006, 34, 3599-3608.

98) C. Brochwitz, A. Feldhoff, U. Kunz, M. Vaultier, A. Kirschning:

Comparison and Evaluation of Two Immobilisation Techniques for Task Specific Onium Salts (TSOS) in Mizoroki-Heck Cross Coupling Reactions

Lett. Org. Chem. 2006, 3, 442-446.

97) A. Kirschning, W. Solodenko, K. Mennecke:

Combining Enabling Techniques in Organic Synthesis – Continuous Flow Processes with Heterogenized Catalysts

Chem. Eur. J. 2006, 12, 5972-5990.

96) T. Kubota, M. Brünjes, T. Frenzel, J. Xu, A. Kirschning, H. G. Floss:

Determination of the Cryptic Stereochemistry of the First PKS Chain-Extension Step in Ansamitocin Biosynthesis by Actinosynnema pretiosum

ChemBioChem 2006, 7, 1221-1225.

95) E. Kunst, A. Kirschning:

Total Synthesis of the Trisaccharide Unit of the Molecular Chaperone Down-Regulator Versipelostatin

Synthesis 2006, 2397-2403.

94) W. Solodenko, K. Mennecke, C. Vogt, S. Gruhl, A. Kirschning:

Polyvinylpyridine, a versatile solid phase for coordinative immobilisation of palladium precatalysts – Applications in Suzuki-Miyaura reactions

Synthesis 2006, 1873-1881.

93) W. Solodenko, P. Bröker, J. Messinger, U. Schön, A. Kirschning:

Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine

Synthesis 2006, 461-466.

92) C. Kujat, M. Bock, A. Kirschning:

Synthesis of the C1-C5 and C6-C24 Fragments of the RNA Polymerase Inhibitors Ripostatin A an B

Synlett 2006, 419-422.

91) T. Frenzel, M. Brünjes, M. Quitschalle, A. Kirschning:

Synthesis of the N-Acetylcysteamine Thioester of seco-Proansamitocin

Org. Lett. 2006, 8, 135-138.


90) K. M. Dawood, A. Kirschning:

Combining enabling techniques in organic synthesis – solid-phase-assisted catalysis under microwave conditions using a stable Pd(II)-precatalyst

Tetrahedron 2005, 61, 12121-12130.

89) K. Mennecke, K. Grela, U. Kunz, A. Kirschning:

Immobilisation of the Grubbs III Metathesis Catalyst with Polyvinyl Pyridine (PVP)

Synlett 2005, 2948-2952.

88) W. Solodenko, C. Brochwitz, R. Wartchow, Md. Abul Hashem, K. Dawood, M. Vaultier, A. Kirschning:

2-Pyridine aldoxime, a new ligand for a Pd-precatalyst – Application in solid-phase-assisted Suzuki-Miyaura reaction

Mol. Diversity 2005, 9, 4, 333-339.

87) U. Kunz, H. Schönfeld, W. Solodenko, G. Jas, A. Kirschning:

Manufacturing and Construction of PASSflow Reactors and their Utilization in Suzuki-Miyaura Cross-coupling Reactions

Ind. Eng. Chem. Res. 2005, 44, 8458-8467.

86) K. Kloth, M. Brünjes, E. Kunst, T. Jöge, F. Gallier, A. Adibekian, A. Kirschning:

Practical TEMPO-Mediated Oxidation of Alcohols using Different Polymer-Bound Co-Oxidants

Adv. Synth. Catal. 2005, 347, 1423-1434.

85) U. Kunz, A. Kirschning, H.-L. Wen, W. Solodenko, R. Cecilia, C.O. Kappe, T. Turek:

Monolithic polymer/carrier materials – Versatile composites for fine chemical synthesis

Catalysis Today 2005, 105, 318-324.

84) L. Elling, C. Rupprath, N. Günther, U. Römer, S. Verseck. P. Weingarten, G. Dräger, A. Kirschning, W. Piepersberg:

An Enzyme Module System for the Synthesis of dTDP-activated Deoxysugars from dTMP and Sucrose

ChemBioChem 2005, 6, 1423-1430.

83) C. Jasper, R. Wittenberg, M. Quitschalle, J. Jakupovic, A. Kirschning:

Total Synthesis and Elucidation of the Absolute Configuration of the Diterpene Tonantzitlolone

Org. Lett. 2005, 7, 3, 479-482.


82) J. Jaunzems, B. Oelze, A. Kirschning:

Preparation of macrocyclic 15N-labelled oligoaminodeoxy-saccharides as probes for RNA-binding

Org. Biomol. Chem. 2004, 3448-3456.

81) A. Kirschning, G. Jas, U. Kunz:

Chemistry in Flow – New Continuous Flow Reactors in Organic Synthesis, Innovation and Perspectives in Solid Phase Synthesis – Combinatorial Libraries

Mayflower Worldwide Ltd. 2004, 129-138.

80) W. Solodenko, H. Wen, S. Leue, F. Stuhlmann, G. Sourkouni-Argirusi, G. Jas, H. Schönfeld, U. Kunz, A. Kirschning:

Development of a Continous-Flow System for Catalysis with Palladium(0) Particles

Eur. J. Org. Chem. 2004, 3601-3610.

79) A. Kirschning, G. Jas:

Applications of immobilized catalysts in continuous flow processes

Topics in Current Chemistry, Springer 2004.

78) J. Jaunzems, D. Kashin, A. Schönberger, A. Kirschning:

Polymer-Bound Diphenylphosphane Hydrobromide, a Mild Acid for the Activation of Enol Ethers – Applications in Polymer-Assisted Glycosidations

Eur. J. Org. Chem. 2004, 3435-3446.

77) W. Solodenko, U. Schön, J. Messinger, A. Glinschert, A. Kirschning:

Microwave-Assisted Suzuki-Miyaura Reactions with an Insoluble Pyridine-Aldoxime Pd-Catalyst

Synlett2004, 10, 1699-1702.

76) M. Brünjes, C. Kujat, H. Monenschein, A. Kirschning:

Acylation of Alkyl Halides and Amino Aldehydes with a Phosphane Oxide based d1-Synthon

Eur. J. Org. Chem. 2004, 1149-1160.

75) A. Kirschning, G.-w. Chen, J. Jaunzems, M. Jesberger, M. Kalesse, M. Lindner:

Synthesis of extended spacer-linked neooligodeoxysaccharides by metathesis olefination and evaluation of their RNA-binding properties

Tetrahedron 2004, 60, 3505-3521.

74) R. Wittenberg, C. Beier, G. Dräger, G. Jas, C. Jasper, H. Monenschein, A. Kirschning:

Towards the total synthesis of Tonantzitlolone – preparation of key fragments and the complete carbon backbone

Tetrahedron Lett. 2004, 45, 4457-4460.


73) G. Jas, A. Kirschning:

Continuous Flow Techniques in Organic Synthesis

Chem. Eur. J. 2003, 9, 5708-5723.

72) U. Kunz, H. Schönfeld, A. Kirschning, W. Solodenko:

Polymer/Carrier composites as materials and reactors for organic synthesis

J. Chromatogr. A 2003, 1006, 241-249.

71) T. Frenzel, W. Solodenko, A. Kirschning:

Solid-Phase Bound Catalysts – Properties and Applications

Polymeric Materials in Organic Synthesis and Catalysis, Wiley-VCH 2003, 201-240.

70) U. Schön, J. Messinger, N. Merayo, G. Juszkiewicz, A. Kirschning:

A Polymer-Bound 1,3-Diketone – A Highly Efficient Scavenger for Hydrazines and Primary Amines

Synlett 2003, 7, 983-986.

69) A. Kirschning, E. Kunst, M. Ries, L. Rose, A. Schönberger, R. Wartchow:

Polymer-bound haloate(I) anions by iodine(III)-mediated oxidation of polymer-bound iodide: Synthetic utility in natural product transformations

Archive for Organic Chemistry2003, 6, 145-163.

68) M. Brünjes, G. Sourkouni-Argirusi, A. Kirschning:

Polymer-Supported Bisacetoxybromate(I) Anion – An Efficient Co-Oxidant in the TEMPO-Mediated Oxidation of Primary and Secondary Alcohols

Adv. Synth. Catal. 2003, 345, 635-642.

67) B. Luy, G. Hauser, A. Kirschning, S. J. Glaser:

Optimierte NMR-Methode zur Bestimmung der Konfiguration chemisch äquivalenter vicinaler Protonen

Angew. Chem. 2003, 115, 1338-1341.

66) J. Jaunzems, E. Hofer, M. Jesberger, G. Sourkouni-Argirusi, A. Kirschning:

Solid-Phase-Assisted Solution-Phase Synthesis with Minimum Purification – Preparation of 2-Deoxyglycoconjugates from Thioglycosides

Angew. Chem. Int. Ed. 2003, 42, 1166-1170.

65) J. Jaunzems, G. Sourkouni-Argirusi, M. Jesberger, A. Kirschning:

Anomeric activation of thioglycosides and preparation of deoxyglycosides using polymer-bound iodate(I) complexes

Tetrahedron Lett. 2003, 44, 637-639.

64) A. Kirschning, R. Wittenberg:

Merging Solid-Phase and Solution-Phase Synthesis – The “Resin-Capture-Release” Hybrid Technique

Organic Synthesis Highlights V, Wiley-VCH 2003, 265-279.


63) U. Kunz, A. Kirschning:

“A new Microreactor for the Solution-Phase Synthesis of Potential Drugs” M. Matlosz, W. Ehrfeld, J. P. Baselt (Editors)

Microreaction Technology Proceedings of the Fifth International Conference on Microreaction Springer-Verlag Berlin- Heidelberg- New York, ISBN 3-540-42498-9, (2002), 424-445

62) G. Dräger, W. Solodenko, J. Messinger, U. Schön, A. Kirschning:

A new reagent and its polymer-supported variant for the amidation of amines

Tetrahedron Lett. 2002, 43, 1401-1403.

61) H. Monenschein, M. Brünjes, A. Kirschning:

Lithiated Dimethoxymethyl Diphenyl Phosphine Oxide, A Versatile Formiate Carbanion Equivalent

Synlett. 2002, 3, 525-527.

60) W. Solodenko, U. Kunz, G. Jas, A. Kirschning:

Polymer-Assisted Horner-Emmons Olefination using PASSflow Reactors: Pure products Without Purification

Bioorg. Med. Chem. Lett. 2002,12, 1833-1835.

59) G.-w. Chen, A. Kirschning:

First Preparation of Spacer-Linked Cyclic Neooligoaminodeoxysaccharides

Chem. Eur. J. 2002, 8, No. 12, 2717-2729.


58) A. Kirschning, R. Wittenberg, H. Monenschein:

Functionalized polymers – Emerging Versatile Tools for Solution-Phase Chemistry and Automated Parallel Synthesis

Angew. Chem. 2001, 113, 670-701; Angew. Chem. Int. Ed.2001, 40, 650-679.

57) A. Kirschning, C. Altwicker, G. Dräger, J. Harders, N. Hoffmann, U. Hoffmann, H. Schönfeld, W. Solodenko, U. Kunz:

PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors

Angew. Chem. Int. Ed. 2001, 40, 3995-3998.

56) S. Domann, G. Sourkoni-Argirusu, N. Merayo, A. Schönberger, A. Kirschning:

Cohalogenation of Allyl and Vinylsilanes using Polymer-bound Haloate(l)-Reagents

Molecules 2001, 6, 127-132.

55) A. Kirschning, M. Jesberger and K. U. Schöning:

Concepts for the Total Synthesis of Deoxy Sugars

Synthesis 2001, 4, 507-540.

54) S. Amann, G. Dräger, C. Rupprath, A. Kirschning, L. Elling:

(Chemo)enzymatic synthesis of dTDP-activated 2,6-dideoxysugars as building blocks of polyketide antibiotics

Carbohydr. Res. 2001, 335, 23-32.

53) A. Kirschning, M. Jesberger and A. Schönberger:

The First Polymer-Assisted Solution-Phase Synthesis of Deoxyglycosides

Org.Lett. 2001, 3, 23, 3623-3626.


52) A. Kirschning, G.-w. Chen:

Synthesis of spacer-linked tail to tail dimers derived from a conformationally rigid aminodeoxysugar by olefin metathesis

Synthesis2000, 1133-1137.

51) A. Kirschning, G.-w. Chen, G. Dräger, I. Schuberth, L. F. Tietze:

Synthesis and biological evaluation of new glyco-modified angucyclin-antibiotics

Bioorg. Med. Chem. 2000, 8, 2347-2354.

50) A. Kirschning:

Borohydride exchange resins (BER) – a group of versatile and powerful polymer-supported reductants

J. Prak. Chem. 2000, 342, 508-511.

49) M. Jesberger, J. Jaunzems, A. Jung, G. Jas, A. Schönberger, A. Kirschning:

Soluble versus insoluble polymers as supports for the prepration of new glycosteroids – a practicability study

Synlett 2000, 1289-1293.

48) D. Hoffmeister, K. Ichinose, S. Domann, B. Faust, A. Trefzer, G. Dräger, A. Kirschning, C. Fischer, E. Künzel, D. W. Bearden, J. Rohr, A. Bechthold:

The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster

Chem. Bio. 2000, 7, 821-831.

47) G. Sourkouni-Argirusi, A. Kirschning:

A new polymer-attached reagent for the oxidation of primary and secondary alcohols

Org. Lett.2000, 2, 3781-3784.

46) A. Kirschning, R. Wittenberg, H. Monenschein:

The “resin-capture-release” hybrid technique: a merger between solid- and solution phase synthesis

Chem. Eur. J. 2000, 6, 4445-4450.


45) S. Lee, A. Kirschning, M. Müller, C. Way, H. G. Floss:

Enzymatic Synthesis of [7-14C,-3H]- and [1-13C]-Sedoheptulose-7-phosphate and [1-13C]-ido-heptulose-7-phosphate

J. Mol. Cat. B. Enzym. 1999, 6, 369-377.

44) A. Kirschning, U. Hary, C. Plumeier, M. Ries, L. Rose:

Simple oxidation of 3-O-silylated glycals: application in deblocking 3-O-protected glycals

J. Chem. Soc., Perkin 1, 1999, 519-528.

43) A. Kirschning, C. Oelkers, M. Ries, A. Schönberger, S.-E. Wohlert, J. Rohr:

Studies on Deoxysugars: Biosynthesis and Implications for Enzyme-Mediated Synthesis of Deoxygenated Oligosaccharides

In New Aspects in Bioorganic Chemistry, Hrsg. U. Diederichsen, Th. K. Lindhorst, L. Wessjohann, B. Westermann. Wiley-VCH, 1999.

42) K.-U. Schöning, R. K. Hayashi, D. R. Powell, A. Kirschning:

Synthetic Studies Toward Ansatrienines: Application of the Evans-Tishchenko Reaction to Chiral Enones

Tetrahedron Asymm.1999, 10, 817-820.

41) H. Monenschein, G. Dräger, A. Jung, A. Kirschning:

Asymmetric Nucleophilic Acylation of Aldehydes via 1,1-Heterodisubstituted Alkenes

Chem. Eur. J. 1999, 5, 2270-2280.

40) A. Kirschning, G. Chen:

Syntheses of Spacer-linked Neodisaccharides Derived from L-Daunosamine

Tetrahedron Lett. 1999, 40, 4665-4668.

39) A. Kirschning, Md. A. Hashem, H. Monenschein, L. Rose, K.-U. Schöning:

Novel Preparation of Haloazide, Equivalents, by Iodine(III)-Promoted Oxidation of Halide Anions

J. Org. Chem. 1999, 64, 6522-6526.

38) A. Kirschning, H. Monenschein, C. Schmeck:

Stable Polymer-Bound Iodine Azide

Angew. Chem. Int. Ed. 1999, 38, 2594-2596.

37) A. Kirschning, M. Jesberger, H. Monenschein:

New polymer-bound electrophilic reagents: applications for the 1,2-functionalization of glycals

Tetrahedron Lett. 1999, 40, 8999-9002.

36) H. Monenschein, G. Sourkouni, K. M. Schubothe, T. O´Hare, A. Kirschning:

Reactions of alkenes, alkynes, and alkoxyallenes with new polymer-supported electrophilic reagents

Org Lett. 1999, 1, 2101-2104.


35) A. Kirschning, C. Plumeier, L. Rose:

Phosphonium Salts of Diacetoxyiodine(I)anions, New Reagents for the Iodoacetoxylation of Alkenes

Chem. Commun. 1998, 11, 33-34.

34) Md. A. Hashem, A. Jung, M. Ries, A. Kirschning:

Iodine(III)-Initiated Bromoacetoxylation of Olefins

Synlett 1998, 195-197.

33) A. Kirschning:

(Diacetoxyiodo)benzene DIB – A Multitalented Oxidant in Organic Synthesis

J. Prakt. Chem. 1998, 340, 184-186.

32) A. Kirschning, G. Dräger, A. Garming, R. Thiericke, M. Zerlin, C. Maul, M. Noltemeyer:

First glycosylation of decarestrictine B and D: A Route to “Hybride” Antibiotics

Chem. Eur. J. 1998, 4, 1324-1331.

31) A. Kirschning:

Hypervalent Iodine and Carbohydrates – A new Liaison

Eur. J. Org. Chem. 1998, 2267-2274.

30) N. Bräuer, A. Kirschning, E. Schaumann:

A Silicon-mediated Synthesis of 3-Deoxy-D-manno-octulosonic Acid (KDO)

Eur. J. Org. Chem. 1998, 2729-2732.


29) A. Kirschning, G. Dräger, A. Jung:

A New Enantioselective Formylation of Aldehydes

Angew. Chem.Int. Ed. Engl. 1997, 36, 253-255.

28) A. Kirschning, M. Ries, S. Domann, W. Martin, W. Albrecht, S. Laufer:

Synthesis of the 1-O-Acyl Glucuronide of the Antiinflammatory Drug ML-3000

Bioorg. Med. Chem. Lett. 1997, 7, 903-906.

27) A. Kirschning, A. Bechthold, J. Rohr:

Biochemical Aspects of Deoxysugars and therefrom derived Oligosaccharides

Topics in Current Chemistry, Springer Verlag 1997, Band 188, 1-84.

26) J. Rohr, S.-E. Wohlert, C. Oelkers, A. Kirschning, M. Ries:

Biosynthetic Short Activation of the 2,3,6-Trideoxysugar L-Rhodinose

Chem. Commun.1997, 10, 973-974.

25) A. Kirschning, J. Harders:

Addition of C-Nucleophiles to Carbohydrate-Derived 2,3-Dihydro-4H-pyran-4-ones: A New Entry to Thromboxane Analogues

Tetrahedron 1997,53, 7867-7876.

24) J. Harders, A. Garming, A. Jung, V. Kaiser, H. Monenschein, M. Ries, L. Rose, K.-U. Schöning, T. Weber, A. Kirschning:

Product Analysis in the Iodine(III)-Promoted Oxidation of Carbohydrate-Derived Cyclic Enol Ethers: A Mechanistic Study

Liebigs Ann. Chem.1997, 2125-2132.

23) A. Kirschning, A. Jung, M. Ries, L. Rose:

Iod(III)-initiierte Glycosidsynthesen, In Chemie Nachwachsender Rohstoffe

Symposium, Wien, 1997, S. 93-97.

22) S. Gaisser, A. Trefzer, S. Stockert, A. Kirschning, A. Bechthold:

Cloning of an Avilamycin Biosynthetic Gene Cluster from Streptomyces viridochromogenes Tü 57

J. Bacteriol. 1997, 179, 6271-6278.


21) A. Kirschning, J. Harders:

Addition of Silyl- and Stannylanions to Carbohydrate-Derived 2,3-Dihydro-4H-pyran-4-ones: Facile Access to Silyl- and Stannyl Glycosides

Synlett 1996, 772-774.

20) G. Dräger, A. Kirschning, R. Thiericke, M. Zerlin:

Decanolides, 10-Membered Lactones from Natural Origin

Natural Products Reports 1996, 13, 365-375.

19) C.-G. Kim, A. Kirschning, P. Bergon, P. Zhou, E. Su, B. Sauerbrei, S. Ning, Y. Ahn, M. Breuer, E. Leistner, H. G. Floss:

Biosynthesis of 3-Amino-5-hydroxybenzoic Acis, the Precursor of mC7N Units in Ansamycin Antibiotics

J. Am. Chem. Soc. 1996, 118, 7486-7491.

18) T. Michel, A. Kirschning, C. Beier, N. Bräuer, E. Schaumann, G. Adiwidjaja:

Synthesis of Functionalized Carbocycles of Different Ring-Size by a Silicon-Induced Cascade Reaction

Liebigs Ann. Chem. 1996, 1811-1821.

17) A. Kirschning, G. Dräger:

Glycosylierte Decarestrictine – ein Beispiel für hybrid aufgebaute Wirkstoffe

GIT 1996, 1224-1226.


16) G. Adiwidjaja, H. Flörke, A. Kirschning, E. Schaumann:

Electrophile-Induced Cyclizations of Silyl-Substited 4-Alken-1-ols

Liebigs Ann. Chem. 1995, 501.

15) A. Kirschning:

Oxidation of Fully Protected Glycals by Hypervalent Iodine Reagents

J. Org. Chem. 1995, 60, 1228.

14) A. Kirschning, U. Hary, M. Ries:

Syntheses of Specifically Labeled 2,3,6-Trideoxyhexoses

Tetrahedron 1995, 51, 2297.

13) A. Kirschning, S. Domann, G. Dräger, L. Rose:

Iodine(III)-Promoted Azide Transfer to 3-Deoxyglycals

Synlett 1995, 767.

12) A. Kirschning:

3,4-Di-O-tert.-butyldimethylsilyl-6-Op-tosyl-D-glucal: A Probe for Mechanistic Studies on Iodine(III)-Promoted Oxidation of Glycals

Liebigs Ann. Chem. 1995, 2053.

11) G. Adiwidjaja, H. Flörke, A. Kirschning, E. Schaumann:

Cyclizations of 5-Silyl-Substituted 4,5-Epoxy-1-alkanols: A Configuration Dependent Mode of Ring Closure

Tetrahedron Lett. 1995, 36, 8771.


10) M.-R. Fischer, A. Kirschning, T. Michel, E. Schaumann::

Cyclopentanole durch eine Silicium-induzierte Reaktionskaskade

Angew. Chem.1994, 106, 220; Angew. Chem. Int. Ed. Engl.1994, 33, 217.

9) A. Kirschning, P. Bergon, J. J. Wang, S. Breazeale, H. G. Floss:

Synthesis of 4-amino-3,4-dideoxy-D-arabino-heptulosonic-acid-7-phosphate, the Biosynthetic Precursor of C7N-Units in Ansamycin Antibiotics

Carbohydr. Res. 1994, 256, 245.


8) A. Kirschning, G. Dräger, J. Harders:

Regioselective Oxidation of Glycals with Hypervalent Iodine Reagents

Synlett1993, 289.

7) A. Kirschning, M. Kreimeyer, H.-P. Blanke:

Regioselective Protection of threo-2,3-Dihydroxybutanoic Esters

Tetrahedron: Asymmetry 1993, 4, 2347-2350.


6) C. G. Kim, A. Kirschning, P. Bergon, Y. Ahn, J. J. Wang, M. Shibuya, H. G. Floss:

Formation of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC(7)N Units in Ansamycin Antibiotics, by a new Variant of the Shikimate Pathway

J. Am. Chem. Soc. 1992, 114, 4941-4943.


5) A. Kirschning, F. Narjes, E. Schaumann:

Synthese von rac-Norartemeseol

Liebigs Ann. Chem. 1991, 933.

4) E. Schaumann, A. Kirschning, F. Narjes:

Synthesis of Vinylcyclopropanes from Epoxides

J. Org. Chem. 1991, 56, 717-723.


3) E. Schaumann, A. Kirschning:

Iodonium-induced Cyclizations of 5-Silylalk-4-enols

J. Chem. Soc. Perkin Trans. I 1990, 1481-1483.

2) E. Schaumann, A. Kirschning:

Regiospecific Synthesis of 1-Silyl substituted 1,4-Dienes

J. Chem. Soc. Perkin Trans. I 1990, 419-421.


1) E. Schaumann, A. Kirschning:

Ring-Opening of Oxiranes by Silyl-substituted Allyl Anions

Tetrahedron Lett. 1988, 29, 4281-4284.

other contributions

XI) A. Kirschning, S. Eichner, J. Hermane, T. Knobloch:

Mutant manufacturers

Drug Discovery from Natural Products 2012, 58-78 more

X) T. Knobloch, F. Taft, A. Kirschning:

Naturstoffbibliotheken – Mutanten können mehr

Nachr. Chemie 2010, 58, 23-28.

IX) A. Kirschning:

Applications of Hypervalent Iodine In Natural Product Synthesis

Proc. 9th Int. Symp.on Iodine Utilization 2006,143-154.

VIII) G. Dräger, A. Kirschning (coauthors):

Trendbericht Organische Chemie (Kohlenhydrate) 2005

Nachr. Chem. Tech. Lab. 2006, 246-247.

VII) A. Kirschning (coauthor):

Trendbericht Organische Chemie (Kohlenhydrate) 2004

Nachr. Chem. Tech. Lab. 2005, 251-272.

VI) A. Kirschning (coauthor):

Trendbericht Organische Chemie (Kohlenhydrate) 2003

Nachr. Chem. Tech. Lab. 2004, 271-273.

V) A. Kirschning, G. Jas, U. Kunz:

Chemistry in flow – new continuous flow reactors in organic synthesis

Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries (Ed. R. Epton), Mayflower Worldwide Ltd. 2004, 129-138.

IV) A. Kirschning, H. Monenschein:

Polymer-bound ammonium bisazidoiodate (I)

e-EROS 2002

III) A. Kirschning, H. Monenschein:

Polymer-bound ammonium bisacetoxybromate (I)

e-EROS 2002

II) A. Kirschning, H. Monenschein:

Polymer-bound ammonium bisacetoxyiodate (I)

e-EROS 2002

I) A. Kirschning*, G. Dräger:

Glycosylierte Decarestrictine – ein Beispiel für hybrid aufgebaute Wirkstoffe

GIT 1996, 1224-1226.

2010 – 2018


2011  2012  2013

2014  2015  2016

2017 2018


2000 – 2009


2001  2002  2003

2004  2005  2006

2007  2008  2009


1990 – 1999


1991  1992  1993

1994  1995  1996

1997  1998  1999


1988 – 1989


other contributions

Natural product synthesis

Natural Product Synthesis


structure elucidation

total synthesis


In the field of natural products we particularly focus on new natural products that exhibit unique biological or pharmacological activities or whose biological targets are of interest for cell biology. Presently, the research group investigates natural products with a potential role as antiinfectives, biofilm inhibitors and compounds showing antiviral activity.

1. Structure elucidation and total synthesis (since 2005)

Elansolids A1/A2


Isolated from gliding bacterium Chitinophaga (formerly Flexibacter),

antibacterical activity (including Staphylococcus aureus and Micrococcus luteus),

two conformationally fixed isomers (atropisomers),

Elansolids B1, B2 and C also reported.

Isolation & structure elucidation:

with R. Dehn, N. Schläger et al., Angew. Chem. Int. Ed. 2011, 50, 532-536. more


with R. Dehn, A. Weber et al., Angew. Chem. Int. Ed. 2011, 50, 3882-3887. more

Total synthesis:

with A. Weber, R. Dehn et al., Org. Lett. 2014, 16, 568-571. more

with L.L.Wang,D. Candito et al.,Chem. Eur. J. 2017, 23, 5291-5298.more

with L.L.Wang ,Beilstein J. Org. Chem. 2017, 13, 1280-1287.more

Collaborations: R. Müller (Saarbrücken), HZI Braunschweig)



Isolated from myxobacterium Sorangium cellulosum,

Biofilm growth inhibition 0.005 µg/mL (35 % of Streptococcus mutans die )

Planktonic cultures are insensitive to Carolacton.

Isolation & structure elucidation:

with T. Schmidt, M. Bock et al., Eur. J. Org. Chem. 2010, 1284-1289. more

Total synthesis:

with T. Schmidt et al., Angew. Chem. Int. Ed. 2012, 51, 1063-1066. more

Biological activity

with  T. Schmidt, J. Ammermann et al., Org. Biomol. Chem. 2015, 13, 5765-5774. more

Scientific Rep. 2016, 6 : 29677. more

Collaborations: R. Müller (Saarbrücken), I. Wagner-Döbler (HZI, Braunschweig), M. Stiesch (MH Hannover)

Noricumazol A


Isolated from myxobacterium Sorangium cellulosum,

strong hepatitis C virus (HCV) inhibitor ,

inhibitor of potassium channel KcsA (by stabilization of its tetrameric architecture)

moderate cytotoxicity

Noricumazol B and C, Icumazoles also reported.

Isolation & structure elucidation:

with J. Barbier et al., Angew. Chem. Int. Ed. 2012, 51, 1256-1260. more

Total synthesis:

with J. Barbier, S. Benson, J. Wegner et al., Chem. Eur. J. 2012, 18, 9083-9090. more

Collaborations: R. Müller (Saarbrücken), T. Pietschmann (TwinCore Hannover), C. Zeilinger (LU Hannover)

Thuggacin A


Isolated from myxobacterium Sorangium cellulosum,

strong antibiotic activity (including Mycobacterium tuberculosis),

targeting the bacterial respiratory chain,

Thuggacin B and C also reported.

Isolation & structure elucidation:

with M. Bock et al., Angew. Chem. Int. Ed. 2008, 47, 2308-2311. more

Total synthesis:

with M. Bock et al., Angew. Chem. Int. Ed. 2008, 47, 9134-9137. more


with J. Franke et al. Chem. Eur. J. 2015, 21, 4272-4284. more 

Collaborations: R. Müller (Saarbrücken), HZI (Braunschweig), F. Bange (MH Hannover)



Isolation from the endemic Mexican plant Stillingia sanguinolenta,

moderate antitumor activity (human breast and kidney cancer cell lines), likely to inhibit kinesines,

Tonantzitlolone B also reported.

Isolation & structure elucidation:

with G. Dräger, X. A. Dominguez, F. Jeske, J. Jakupovic et al., Eur. J. Org. Chem. 2007, 5020-5026. more

Total synthesis:

with C. Jasper, R. Wittenberg et al., Org. Lett. 2005, 7, 479-482. more



Isolation from Streptomyces collinus

moderate antibacterial and antifungal activity

Ansatrienin B also reported.

Total synthesis:                           

with K.-U. Schöning, A. Meyer, D. Kashin, R. Wittenberg et al., Synthesis 2007, 304-319. more

Millingtonine A


Isolated from flower buds of Millingtonia hortensis

Millingtonia hortensis is an important source of herbal medicine in Southeast Asia.

Total synthesis:                                                    

with J. Wegner, S. V. Ley, I. Baxendale, et al., Org. Lett.2012, 14, 696-699. more

Collaborations: Leading groups of this project: Ley&Baxendale, Cambridge, UK.

Cystobactamid 861-2

Isolated from  Cystobacter sp.

Strong antibacterial activity and inhibitor of bacterial topoisomerase

Other cystobactamids have also been reported

Isolation and structural elucidation and total synthesis:                                          

T. Planke, M. Brönstrup, R Müller et al., Angew. Chem. Int. Ed. 2017, 56,12760- 12764. more

Partial synthesis:

with M. Moreno et al., Synlett  2015, 1175- 1178. more
Collaborations: M. Brönstrup (HZI, Braunschweig) & R. Müller (HIPS,Saarbrüken)

Disciformycin A & B


Isolated from  Pyxidicoccus fallax AndGT8.

Strong antibacterial activity including methicillin- and vancomycin-resistant Staphylococcus aureus

Structurally related gulmericins were also reported by Nett et al.


 M.Wolling, Eur. J. Org. Chem 2018 (accepted manuscript)   


Collaborations: AK Müller (HZI,Braunschweig)


 Research fileds

Click on the links below to learn more about the according research fileds of the Kirschning group.

Natural Product Synthesis


Flow Chemistry




Click on the link below for access to all publications.


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