The Kirschning Group

Rebirth

Rebirth

Tissue engineering

Cancer therapy

The group around Dr. Gerald Dräger and Prof. Dr. Andreas Kirschning involved in the cluster of excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy) strongly focus on the development of cardiac tissue formation using polysaccharides as extracellular matrix (ECM). We developed a cross-linking method using the hydrazone formation of modified polysaccharide-aldehydes and hydrazides. This method was applied on various polysaccharides such as hyaluronic acid, alginate, dextran, pullulan, glycogen, cellulose and others.

 

We successfully applied this cross-linking method on various polysaccharides like alginate and hyaluronic acid to perform several tissue engineering experiments resulting in a novel myocardial tissue based on polysaccharides.

 

Besides the modification of polysaccharides with respect to later crosslinkage, we produce and use the cyclic pentapeptide RGDfK to enhance the biocompatibility and cell adhesion of our materials. Therefore, we successfully studied the [1,3]-dipolar cycloaddition between an azide-modified RGDfK and a linker-modified polysaccharide.

Our current aim is the development of new crosslinking methods and their application on a library of polysaccharides with different origin. Besides, we are focusing on the synthesis of monomeric model systems of the used polysaccharides. Through those we were able to elucidate the structure of different sideproducts via NMR comparison with the modified polysaccharides.

 

Another topic of high importance for the REBIRTH group is the mutasynthetic approach to a semisynthetic access to ansamytocin. Ansamitocins are natural products with high cytotoxic properties in the low nanomolar range that are produced by the microorganism A. pretiosum. Therefore, these are very interesting compounds for medical applications. Mutasynthesis in combination with the precursor directed biosynthesis (PDB) and semisynthesis can lead to new natural product derivatives of ansamitocins that can be attached to superparamagnetic nanoparticles by a thermocleavable linker system.

Here, our group developed a method after which the ansamytocin-nanoparticle conjugate can be released via inductive heating procedure. Through the use of an alternating magnetic field a high temperature gets applied on the nanoparticle and hence a retro-Diels-Alder induced that leads to a precise and local release of the desired drug. In our case the derivatives of ansamytocin.

We combined this system with a hyperthermia approach for several studies as alternative to chemotherapy as cancer treatment.

 

 Research fileds

Click on the links below to learn more about the according research fileds of the Kirschning group.

Natural Product Synthesis

Mutasynthesis

Flow Chemistry

Rebirth

Methodological

Publications

Click on the link below for access to all publications.

 

publications

 

legal information

Legal Information

 

Institut for Organic Chemistry

 

Leibniz University of Hannover
Schneiderberg 1B
30167 Hannover
GERMANY

Impressum

 

Gottfried Wilhelm Leibniz
Universität Hannover
Welfengarten 1
30167 Hannover
Tel. +49 511.762-0
Fax +49 511.762-3456
Vertreten durch:  

Präsident
der Leibniz Universität Hannover

Name der Einrichtung:

Arbeitskreis Prof. Kirschning

Leibniz Universität Hannover
Institut für Organische Chemie
Schneiderberg 1 B
30167 Hannover

vertreten durch:  

 

Andreas Kirschning

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Web-Redaktion:  

Egor Geist

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A. Kirschning

Prof. Dr. Andreas Kirschning

 

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Andreas Kirschning was born in Hamburg and studied chemistry at the University of Hamburg and at Southampton University (UK). In Hamburg he joined the group of Prof. E. Schaumann and received his Ph. D. there in 1989. After a postdoctoral stay at the University of Washington (Seattle) with Prof. H. G. Floss, he started his independent research at the Technical University of Clausthal in 1991. Since then he has held positions as guest professor at several universities across Europe and in the U.S.A.. He received during his career a DAAD, a Fritz Prosiegel and Feodor Lynen scholarship. Since 2000 he holds a chair at the University of Hannover.

Biography

10/80-08/86

Chemistry studies at the University of Hamburg

10/83-07/84

Chemistry studies at Southampton University, UK;      final examination for B. Sc.

08/86

Diploma thesis (Prof. Dr. E. Schaumann, University of Hamburg)

04/89

Ph.D. thesis (Prof. Dr. E. Schaumann, University of Hamburg) on synthetic organo-silica chemistry

08/89-10/90

Post-doctoral fellowship with Prof. H. G. Floss (University of Washington, Seattle, USA): Biosynthetic studies on macrolactam antibiotics

04/91- 06/96

Habilitation (Technical University of Clausthal): Synthetic and biosynthetic studies on deoxyglycoconjugates

since 10/2000

Professor at the Institute of Organic Chemistry, Leibniz University of Hannover

Main research topics

Enabling technologies in organic synthesis:

Microstructured flow reactors, inductive heating, multistep flow synthesis of drugs

Natural product chemistry:

Total, semi- and mutasynthesis of biologically active natural products: antiinfectives, antitumor agents,antiviral agents; natural products as tools for drug; finding and evaluation of  biological targets.

Chemistry as tool in RegenerativeTherapies:

Biocompatible (bio)materials for medical implants: synthesis of materials, surface functionalisation, drugable molecules for stem cell research

Fellowships / Awards

DAAD-study scholarship for UK (1983-84)
Fritz-Prosiegel-scholarship (1989)
Feodor-Lynen-scholarship of the Alexander-von-Humboldt-Foundation (1989-90)

Novartis Lectureship Award (2013)

Guest professorships

Humboldt-Universität zu Berlin (1997)
University of Wisconsin, U.S.A. (1998)
Université de Rennes, France (2003)
Université Le Mans, France (April/May 2007)
Università di Roma “La Sapienza”, Italy (October 2007)
Université de Strasbourg Ecole européenne de Chimie, Polymères et Matériaux (ECPM) (January-February 2009 to 2011)

Functions

Editor of ROEMPP-online (Thieme Publisher)
Editorial Board J. Flow Chem. (since 2010)
Editorial Board of Natural Product Reports (NPR) (since 2007)
Editorial Board of Beilstein Journal of Organic Chemistry (BJOC) (since 2006)
Director of the Institute of Organic Chemistry, University Hannover (since 02/2001)
Member of the Natural Product Forum of the DECHEMA (since 02/2003)
Board member of the DECHEMA section “Chemical Biology” (2005-2009)
Selection commitee of the Studienstiftung des Deutschen Volkes (since 11/1998)

Memberships

Gesellschaft Deutscher Chemiker (GDCh) (since 1989)
Royal Society of Chemistry (since 2003)
TECHNION Ges. (since 2005)

Teaching

Click on the links below for access to the corresponding download section.

lectures and handouts

practical work

group seminar – open access

group seminar – internal

Current group

Group

order by time of stay

Dr. Gerald Dräger

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Research project: -REBIRTH-

Design of new biomedical polymers and small molecule modulators for stem cell development

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M. Sc. Maik Siebke

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Research project: Natural Product Synthesis

Studies towards the total synthesis of Myxovalargin

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M. Sc. Mona Oltmanns

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Research project: Flow Chemistry

Inductive flow synthesis in supercritical water


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M. Sc. Clara Oberhauser

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Research project: Mutasynthesis

Studies on enzymatic biotransformations 

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M. Sc. Therese Planke

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Research project: Natural Product Synthesis

 Synthesestudien zu den Cystobactamiden

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M. Sc. Peijun Li

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Research project: Natural Product Synthesis

 Studies towards the total synthesis of xenovulenes

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