The Kirschning Group

Methodological

Methodology

TEMPO decarbonylation Umpolung

A new synthetic approach to investigate the potential decarbonylation protocol in polyketide synthesisvia complex N-alkoxyamines starting from 4 hydroxy TEMPO and aldehydes is investigated. The decarbonylation of aldehydes is used for generating 1,2-diols from stereodefined 1,3 diols, which have been obtained by the Evans aldol protocol.

tempo-decarbonylation.jpg

The stereo controlled palladium catalysed umpolung allylation of aldehydes generates two new stereogenic centres and a terminal double bond, making this reaction highly attractive for natural product synthesis.

umpolung.jpg

We could show that the allylation of a-chiral aldehydes can be performed in a highly stereoselective way in a one-pot procedure using Pd(0) catalysis. A variety of aldehydes could successfully be employed obtaining the products in moderate to good yields and promising d.r.´s.

umpolung-bsp.jpg

 Research fileds

Click on the links below to learn more about the according research fileds of the Kirschning group.

Natural Product Synthesis

Mutasynthesis

Flow Chemistry

Rebirth

Methodological

Publications

Click on the link below for access to all publications.

publications


Scroll to top
www.000webhost.com