The Kirschning Group

Natural product synthesis

Natural Product Synthesis


structure elucidation

total synthesis


In the field of natural products we particularly focus on new natural products that exhibit unique biological or pharmacological activities or whose biological targets are of interest for cell biology. Presently, the research group investigates natural products with a potential role as antiinfectives, biofilm inhibitors and compounds showing antiviral activity.

1. Structure elucidation and total synthesis (since 2005)

Elansolids A1/A2


Isolated from gliding bacterium Chitinophaga (formerly Flexibacter),

antibacterical activity (including Staphylococcus aureus and Micrococcus luteus),

two conformationally fixed isomers (atropisomers),

Elansolids B1, B2 and C also reported.

Isolation & structure elucidation:

with R. Dehn, N. Schläger et al., Angew. Chem. Int. Ed. 2011, 50, 532-536. more


with R. Dehn, A. Weber et al., Angew. Chem. Int. Ed. 2011, 50, 3882-3887. more

Total synthesis:

with A. Weber, R. Dehn et al., Org. Lett. 2014, 16, 568-571. more

with L.L.Wang,D. Candito et al.,Chem. Eur. J. 2017, 23, 5291-5298.more

with L.L.Wang ,Beilstein J. Org. Chem. 2017, 13, 1280-1287.more

Collaborations: R. Müller (Saarbrücken), HZI Braunschweig)



Isolated from myxobacterium Sorangium cellulosum,

Biofilm growth inhibition 0.005 µg/mL (35 % of Streptococcus mutans die )

Planktonic cultures are insensitive to Carolacton.

Isolation & structure elucidation:

with T. Schmidt, M. Bock et al., Eur. J. Org. Chem. 2010, 1284-1289. more

Total synthesis:

with T. Schmidt et al., Angew. Chem. Int. Ed. 2012, 51, 1063-1066. more

Biological activity

with  T. Schmidt, J. Ammermann et al., Org. Biomol. Chem. 2015, 13, 5765-5774. more

Scientific Rep. 2016, 6 : 29677. more

Collaborations: R. Müller (Saarbrücken), I. Wagner-Döbler (HZI, Braunschweig), M. Stiesch (MH Hannover)

Noricumazol A


Isolated from myxobacterium Sorangium cellulosum,

strong hepatitis C virus (HCV) inhibitor ,

inhibitor of potassium channel KcsA (by stabilization of its tetrameric architecture)

moderate cytotoxicity

Noricumazol B and C, Icumazoles also reported.

Isolation & structure elucidation:

with J. Barbier et al., Angew. Chem. Int. Ed. 2012, 51, 1256-1260. more

Total synthesis:

with J. Barbier, S. Benson, J. Wegner et al., Chem. Eur. J. 2012, 18, 9083-9090. more

Collaborations: R. Müller (Saarbrücken), T. Pietschmann (TwinCore Hannover), C. Zeilinger (LU Hannover)

Thuggacin A


Isolated from myxobacterium Sorangium cellulosum,

strong antibiotic activity (including Mycobacterium tuberculosis),

targeting the bacterial respiratory chain,

Thuggacin B and C also reported.

Isolation & structure elucidation:

with M. Bock et al., Angew. Chem. Int. Ed. 2008, 47, 2308-2311. more

Total synthesis:

with M. Bock et al., Angew. Chem. Int. Ed. 2008, 47, 9134-9137. more


with J. Franke et al. Chem. Eur. J. 2015, 21, 4272-4284. more 

Collaborations: R. Müller (Saarbrücken), HZI (Braunschweig), F. Bange (MH Hannover)



Isolation from the endemic Mexican plant Stillingia sanguinolenta,

moderate antitumor activity (human breast and kidney cancer cell lines), likely to inhibit kinesines,

Tonantzitlolone B also reported.

Isolation & structure elucidation:

with G. Dräger, X. A. Dominguez, F. Jeske, J. Jakupovic et al., Eur. J. Org. Chem. 2007, 5020-5026. more

Total synthesis:

with C. Jasper, R. Wittenberg et al., Org. Lett. 2005, 7, 479-482. more



Isolation from Streptomyces collinus

moderate antibacterial and antifungal activity

Ansatrienin B also reported.

Total synthesis:                           

with K.-U. Schöning, A. Meyer, D. Kashin, R. Wittenberg et al., Synthesis 2007, 304-319. more

Millingtonine A


Isolated from flower buds of Millingtonia hortensis

Millingtonia hortensis is an important source of herbal medicine in Southeast Asia.

Total synthesis:                                                    

with J. Wegner, S. V. Ley, I. Baxendale, et al., Org. Lett.2012, 14, 696-699. more

Collaborations: Leading groups of this project: Ley&Baxendale, Cambridge, UK.

Cystobactamid 861-2

Isolated from  Cystobacter sp.

Strong antibacterial activity and inhibitor of bacterial topoisomerase

Other cystobactamids have also been reported

Isolation and structural elucidation and total synthesis:                                          

T. Planke, M. Brönstrup, R Müller et al., Angew. Chem. Int. Ed. 2017, 56,12760- 12764. more

Partial synthesis:

with M. Moreno et al., Synlett  2015, 1175- 1178. more
Collaborations: M. Brönstrup (HZI, Braunschweig) & R. Müller (HIPS,Saarbrüken)

Disciformycin A & B


Isolated from  Pyxidicoccus fallax AndGT8.

Strong antibacterial activity including methicillin- and vancomycin-resistant Staphylococcus aureus

Structurally related gulmericins were also reported by Nett et al.


 M.Wolling, Eur. J. Org. Chem 2018 (accepted manuscript)   


Collaborations: AK Müller (HZI,Braunschweig)


 Research fileds

Click on the links below to learn more about the according research fileds of the Kirschning group.

Natural Product Synthesis


Flow Chemistry




Click on the link below for access to all publications.


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